Identifies a 53 kDa protein as a product of the p53suppressor gene. It interacts with both the wild and mutantforms of p53. Its epitope is located inside p53’s N-terminus(aa 37–45). In an ELISA assay, the monoclonal antibodyPAb1801 does not prevent DO-7 MAb from binding to p53.A tumour suppressor gene that is expressed in manydifferent tissue types, p53 controls cell division, growth,and death. It attaches itself to the human papillomavirus E6protein, SV40 T antigen, and MDM2. In colorectal, lung,breast, and urothelial cancers, positive nuclear stainingwith p53 antibody has been shown to be a poor predictivefactor. Additionally, anti-p53 positivity has been used toidentify intratubular germ cell neoplasia and distinguishuterine serous carcinoma from endometrioid carcinoma.Many different types of cancerous tumours, such as breast,ovarian, bladder, colon, lung, and melanoma, have p53mutations.