p120 catenin is situated on chromosome 11q11. Both alpha-catenin and beta-catenin connect to the intracellular section of E-cadherin, whereas p120 catenin attaches to E-cadherin at a nearby membrane location. This assembly reinforces tight junctions. Within the cell, p120 catenin is found in the E-cadherin/catenins adhesion complex, forming a direct link with the cytoplasmic C-terminus of E-cadherin and potentially engaging with additional cadherins. A lack of E-cadherin leads to the buildup of p120 catenin within the cytoplasm. In lobular breast carcinoma, there is a notable accumulation of p120 catenin inside the cell, while ductal carcinoma demonstrates less p120 catenin at the membrane without any cytoplasmic build-up. In cases of gastric and colonic carcinoma, significant cytoplasmic p120 catenin correlates with an infiltrative morphology that lacks cohesion.