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Genebiosolution > IHC Primary Antibody > ATRX Antibody

ATRX Antibody

Clone: GR244

As a member of the Snf2 family of helicase/ATPases, ATRX helps to initiate transcription and replication and contributes to the ATP-dependent remodelling of the nucleosome structure. ATRX has a PHD zinc finger motif structurally. ATRX is distributed differently in the nucleus and is controlled during the cell cycle. ATRX localises with condensed chromatin during mitosis, although it mostly interacts with the nuclear matrix during interphase. Phosphorylation quickly causes this shift of ATRX to the short arms of the human acrocentric chromosomes at the start of M phase. It then mediates chromosomal segregation by openly complexing with heterochromatin protein 1 Î±. High rates of severe X-linked syndromal mental retardation connected to Î±thalassemia or ATRX syndrome are correlated with mutations in the ATRX gene.

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Specifications

Species Reactivity

Humans; others not tested

Known Applications

Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As

Buffer with protein carrier and preservative

Storage

Store at 2ºC to 8ºC

Control

High-grade glioma

Visualization

Nuclear

Isotype

IgG

Immunogen

Recombinant fragment (around aa2200-2450) of human ATRX protein

Ordering Information

Format:

Volume:

Classification
RUO
Catalogue Number
G2718RP

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