Product Overview
Clone: 8G7G3/1
TTF-1 belongs to the family of homeodomain transcription factors called NKx2. The thyroid gland and lung epithelial cells both express it. The pituitary, prostate, adrenal glands, liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, and testes all have non-reactive nuclei. Anti-TTF-1 is helpful in distinguishing malignant mesothelioma, mediastinal germ cell tumours, and lung primary adenocarcinoma from breast-derived metastases. Additionally, it can be utilised to distinguish lymphoid infiltrates from small cell lung cancer. Loss of TTF-1 expression in non-small cell lung carcinoma has been connected with aggressive behaviour of such neoplasms. Thyroid cancers also exhibit TTF-1 reactivity.
