A calcium-binding protein that is dependent on vitaminD and participates in calcium signalling is calledcalcretinin. Numerous healthy and diseased tissues, aswell as the central and peripheral nervous systems,express it. It can be used to distinguish between lungtumours and to stain mesothelioma. In the differentialdiagnosis of solid and cystic ameloblastic tumours,calretinin antibody is also regarded as a crucialdiagnostic tool.It has been demonstrated that calretinin antibody ishelpful in distinguishing mesothelioma from lungadenocarcinomas and other types of cancer.Additionally, it helps distinguish betweenpheochromocytomas and adrenal-cortical neoplasms.