All epithelial cells, with the exception of the superficiallayers of squamous epithelium, hepatocyte, and parietalcells, have glycoproteins of 34 and 49 kDa on their surfaceand in their cytoplasm that Ber-EP4 can recognise. It hardlyever marks mesotheliomas and never labels mesothelialcells. It reacts with human epithelial cells in a wide rangeof ways, including simple epithelia, basal layers of stratifiednon-keratinized squamous epithelium, and the epidermis.Other comparable antibodies are MOC-31, ESA [VU-1D9],and AUA1. According to reports, Ber-EP4 can differentiatebetween pleural mesotheliomas and adenocarcinomas.