Glycoproteins in the CD44 group are present as several different versions, with the standard 85-95 kD or hematopoietic variant (CD44s) being the most frequently observed, located in mesodermal cells like hematopoietic, fibroblastic, and glial cells, alongside certain carcinoma cell lines. 1 Epithelial cells have been shown to contain larger molecular weight versions (CD44v), which are believed to be involved in how cells stick together and bind to the stroma. 1 Even though numerous human tumors show CD44, there is evidence of a link between CD44v presence and tumor dedifferentiation.  The use of Anti-CD44 could be beneficial in telling the difference between urothelial carcinoma in-situ and urothelium’s non-cancerous alterations.