Nerve growth factor receptor, referred to as p75NTR, is a glycoprotein weighing 75 kDa, belonging to the tumor necrosis factor receptor group and plays a crucial role in the development of the peripheral nervous system during embryogenesis. In healthy tissue, NGFR is found in cells derived from the neural crest, follicular dendritic cells in lymph nodes and tonsils, and myoepithelial cells in the breast, prostate, and salivary glands, as well as in the basal epithelial layer of the respiratory tract. NGFR has been identified as a valuable marker in the case of melanoma, particularly in its desmoplastic and spindle cell forms. Anti-NGFR can label myoepithelial cells in the breast and might help distinguish between benign conditions, pre-invasive neoplastic lesions, and invasive cancers of the breast.