Special AT-rich sequence-binding protein 2 (SATB2) serves as a marker that acts as a transcription factor associated with the nuclear matrix and has been demonstrated to recognize colorectal carcinomas, including those that are poorly differentiated and metastatic. Additionally, adenocarcinomas, such as those found in the breast, lung, and ovary, may show lower rates of SATB2 expression. Consequently, SATB2 proves valuable for detecting colorectal-origin carcinomas when the primary cancer is unknown.