Cytokeratin 14

Cytokeratin 14

LL002/Mouse/Monoclonal

Alongside keratin-5 (type II or B or basic), cytokeratin-14 (CK14) is a member of the type-I (or A or acidic) subfamily of low-molecular-weight keratins. Basal cells of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells all contain CK14. Squamous cell carcinomas can be distinguished from poorly differentiated epithelial tumours with the help of anti-CK14. One of the particular basal markers used to differentiate between basal and non-basal subtypes of breast carcinomas is anti-CK14. By positively staining the basal cells around the in-situ tumour, anti-CK14 is also an effective marker for differentiating benign prostate from prostate cancer and for differentiating intraductal from invasive salivary duct carcinoma. Additionally, this antibody has been helpful in diagnosing breast metaplastic carcinomas and distinguishing kidney oncocytic tumours from their renal counterparts.

INTENDED USE

For Research Use Only (RUO).