Placental Alkaline Phosphatase (PLAP) (Germ Cell Tumor Marker)

Genebiosolution > Placental Alkaline Phosphatase (PLAP) (Germ Cell Tumor Marker)

Product Overview

Clone: GM022

Anti-PLAP reacts with germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic, and urinary cancers may also immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with anti-keratin negativity favors seminoma over carcinoma. Germ cell tumors are usually anti-keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP has been useful in the diagnosis of gestational trophoblastic disease.

Datasheet

Specifications

Species

Mouse

Immunogen

Recombinant human PLAP protein

Clone

GM022

Isotype

IgG2b, kappa

Species Reactivity

Human. Others not known.

Positive Control

HepG2 cells. Placenta or seminoma.

Specificity

Reacts with a 70kDa membrane-bound isozyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation.

Cellular Localization

Cytoplasmic and cell surface

Ordering Information

Format:

Volume:

  • Classification
  • RUO
  • Catalogue Number
  • G0006RP

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